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Postico vs psequel4/16/2023 ![]() Filter by these if you want a narrower list of alternatives or looking for a specific functionality of Sequel. Sequel Pro alternatives are mainly Database Managers but may also be Relational Databases or Business Intelligence Tools. Despite the higher kidney and liver uptake and retention of compound 7, the simple radiosynthesis and the exceptionally high tumor uptake (SUV 60min 2.11) and retention make radiotracer 7 an interesting alternative to radiotracer DCFPyL for PET imaging of PSMA in prostate cancer.į-18 Positron emission tomography (PET) Prostate cancer Prostate-specific membrane antigen (PSMA). Other interesting Windows alternatives to Sequel Pro are MySQL Workbench, HeidiSQL, DataGrip and Valentina Studio. Radiotracer 7 displayed the highest uptake and retention in LNCaP tumors, which exceeded uptake values of reference compound DCFPyL by more than 100 %. Postico 2 is the next major version coming after Postico 1.5. ![]() Whether you want to enter data, search data, or perform SQL queries, Postico has you covered. Postico offers SQL developers a top-notch SQL editor and query interface to Mac users who work with PostgreSQL databases. Our customers range from researchers and analysts to app developers and students. The observed tumor uptake and clearance profiles demonstrate the importance of the selected prosthetic group on the pharmacokinetic profile of analyzed PSMA-targeting radiotracers. Postico 2 is a database app with a very strong focus on its core audience: people who use databases. Dynamic PET imaging revealed the following SUV 60min for radiotracer uptake in PSMA(+) LNCaP tumors: 0.98 (DCFPyL), 2.11 (7), 0.40 (4), and 0.19 (8). ![]() The IC 50 value of reference compound DCFPyL was 13 nM. Compounds 4 and 8 showed IC 50 values of 13 and 62 nM, respectively. Compound 7 displayed an IC 50 value of 6 nM reflecting very high affinity for PSMA. Tumor uptake and clearance profiles of three F-18-labeled PSMA inhibitors (4, 7, and 8) were studied with dynamic PET imaging using LNCaP tumor-bearing mice.į-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with SFB and (2) oxime formation with 4-fluorobenzaldehyde and FDG using the respective aminooxy-functionalized lysine residue. All fluorine-containing PSMA inhibitors were tested for their PSMA inhibitory potency in an in vitro competitive binding assay in comparison to an established reference compound TAAG-PSMA. ![]() Prosthetic groups N-succinimidyl-4-fluorobenzoate (SFB), 4-fluorobenzaldehyde, and 2-deoxy-2-fluoro-D-glucose (FDG) were used for bioconjugation reactions to PSMA-binding lysine-urea-glutamate scaffold via acylation and oxime formation. Here, we describe the synthesis and radiopharmacological evaluation of various F-18-labeled PSMA inhibitors which were prepared through different prosthetic group chemistry strategies. The favorable positron emission tomography (PET) imaging profile of the PSMA imaging agent 2-(3-(1-carboxy-5-fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentane-dioic acid DCFPyL in preclinical prostate cancer models and in prostate cancer patients stimulated the development and validation of other fluorine-containing PSMA inhibitors to further enhance pharmacokinetics and simplify production methods. Prostate-specific membrane antigen (PSMA) is an important biomarker expressed in the majority of prostate cancers. ![]()
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